Old and Depressed: “Pseudo-Dementia”
Marc Ringel, M.D. & David Stephen, Ph.D.
In this article, Dr. Marc and Dr. Dave, long-time friends, team up to talk about “reversible dementia.”
Dr. Dave: Let’s start with a definition. What is dementia?
Dr. Marc: "Dementia" is a medical term that refers to mental impairment that results in confusion, forgetfulness and inability to function normally at mental tasks.
Dr. Dave: But senile dementia is different than being occasionally forgetful. And there are some kinds of dementia – or abnormal memory loss and confusion – that are reversible.
Dr. Marc: Yes, for some people all or a part of their dementia symptoms are reversible. There is a very long list of causes that a doctor needs to consider when an older person shows a decrease in mental function in the hope of uncovering something treatable. For instance, when the cause is an illness, the symptoms of dementia can often be relieved by treating the illness.
Dr. Dave: That makes sense, Marc. Obviously, when we are ill, we are not operating at peak mental efficiency.
Dr. Marc: Right. We are always looking for treatable causes. In the elderly, the behaviors we associate with dementia, usually confusion and memory loss, can result from a cause as simple as a respiratory or urinary tract infection, low blood sugar, a vitamin deficiency, or stress.
Dr. Dave: But these are not physical ailments specific to the elderly...
Dr. Marc: No, David, but the elderly react differently to many illnesses than younger people do. They may have pneumonia without fever and appendicitis without pain. Depression may also look very different in older people. Sometimes it looks like senility. That’s why we call it "pseudo-dementia."
Dr. Dave: You and I have both had first-hand experience with our own bouts of depression. Many people have. Depression can rob you of joy, make you irrationally irritable, cause lethargy or sleeplessness. Can depression cause dementia?
Dr. Marc: Not so much cause but seem. Depression can seem like dementia. Here’s one of my favorite stories. Every doctor has a few patients who have changed his career. One of mine, long ago, was a woman whose name I don't even remember. Her husband and daughter called her "Mom."
They explained that Mom had been "senile" for about ten years. Her spouse and her only child had devoted a good deal of their lives over the last decade to taking care of her.
Mom was 58 years old. She was a pleasant middle aged woman who could follow simple instructions during my examination. But her answers to my questions were either unrelated to what I had asked or unintelligible.
Something was not right. Forty-eight year olds do not become demented for no good reason. If they do, one expects them to deteriorate over the subsequent ten years. The woman I saw before me was sadly out of it but otherwise quite healthy. So I sent her to see a psychologist who interviewed Mom and performed some psychological tests. He told me he thought she was depressed.
I prescribed an antidepressant for Mom. Within a few weeks her daughter and husband said that they had "gotten her back." After a decade's absence, she resumed her productive role in the family. When I saw her, Mom carried on a completely appropriate conversation with me. That gratifying result helped to make depression one of my favorite diseases to diagnose and treat.
Dr. Dave: That’s an inspiring story, but not everyone is that passive when it comes to talking about depression. Unfortunately, there’s a negative social stigma attached to depression. Many people still feel that it is an embarrassing emotional problem and that makes it hard for people to admit.
Dr. Marc: That’s quite true. But now we understand that depression can be caused by a chemical imbalance. So we treat it as we would, say, pneumonia. We don’t ask “Why do you have pneumonia,” we just say, “That’s pneumonia. We know how to treat it,” and we treat it.
Dr. Dave: I have a client whose son suspects she is depressed and thinks that depression is the cause of her chronic fatigue. She took an antidepressant for about a week, had one good day, and said, “I’m cured!” So she stopped taking the medication. But she still seems fatigued all of the time.
Dr. Marc: That’s unfortunate. You wouldn’t do that with blood pressure medication just because your blood pressure went down after a week. She should stay with the program her doctor prescribed. Depression can be chronic and should be treated for a while before attempting to wean (not suddenly quit) the medication.
Dr. Dave: But how do you know which comes first, depression or the mental distress that people often think is an “emotional problem?”
Dr. Marc: Depression, like most illnesses, has both an emotional and a biological side. Losses – of function, family and friends – can wreak emotional havoc on even the toughest older person. So that emotional distress can lead to emotional depression.
Dr. Dave: Take away the stress and the depression goes away? I mean, people sometimes “just get over it” when they have time to process the event, work through the grieving process, readjust to a change or loss.
Dr. Marc: That can happen. But some of depression is explained by biological factors, namely an imbalance of neurotransmitters, the chemicals that allow the computer in our head to work by carrying messages between brain cells. Antidepressants change the balance of these neurotransmitters so that what comes out is a less depressed person.
Dr. Dave: And a less depressed person may be a person whose dementia has been reversed. It’s ironic that people may be more wiling to accept an irreversible cause of dementia like Alzheimer’s disease than to admit to a potentially reversible cause of dementia like depression.
Dr. Marc: Alzheimer's disease is the most common cause of dementia in the elderly. As anybody who has lived with an Alzheimer's patient knows, the level of impairment can range from trouble with the checkbook to not recognizing one's own spouse.
Unlike Alzheimer's type dementia, up to a third of dementias may be wholly or partially reversible. There are an enormous number of fixable things that can cause mental function to deteriorate, from low thyroid to overmedication. Depression is one of those things.
Dr. Dave: So, how do you determine if the signs of dementia are caused by or related to depression?
Dr. Marc: Much of science is informed trial and error. You think you know the cause and treat that, and if the outcome is positive your diagnosis and treatment were probably right. If not, you go on to a new hypothesis based on what you knew previously and what you have learned did not work.
A depressed elderly person may, for all the world, look just plain demented. The medical workup, including physical exam, blood tests, and x-rays, may all be normal. If so, there is one more thing to try, antidepressants.
Dr. Dave: And that treatment might be as happily correct as the case of the woman you described who made such a remarkable recovery from “pseudo-dementia.”
Dr. Marc: We were all happy about that case. And that taught me to look for more causes for dementia than just being old. Remember that depression in an older person may look like senility. If you suspect that you or someone you care about is depressed, get help. Depression is treatable.
(SIDEBAR)
POTENTIALLY REVERSIBLE CAUSES OF DEMENTIA
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Stroke or heart attack (depending on brain damage and therapy)
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Low blood oxygen levels or low heart rate
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Respiratory or urinary tract infections
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Hypoglycemia (low blood sugar)
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Medication interactions or side effects
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Depression or stress
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Drug or alcohol abuse
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Vitamin deficiency (often B-12)
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Hypothyroidism
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Brain injuries (tumors, subdural hemorrhage & hematoma)
NOT REVERSIBLE
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Alzheimer’s disease
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AIDS
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Parkinson’s
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Stroke (resulting in permanent brain damage)
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Multiple Sclerosis
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Schitzophrenia
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Normal Pressure Hydrocephalus
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Other diseases (Pick’s, Huntington’s, Creutzfeldt-Jakob, Lewy Body, etc.)
(NOTE: Treatment can often lessen symptoms of dementia, even when the cause is non-reversible.)